Ansari F
Pharmacy of Polyclinic, Imam Medical Center, Tehran University of Medical Sciences and Health Services, Iran.
Eur J Clin Pharmacol. 2001 Sep;57(6-7):541-6. doi: 10.1007/s002280100350.
To investigate the pattern of systemic antiinfective use in Bouali teaching hospital (BH) within a standardized methodology.
To perform a standardized and repeatable study, the Anatomic-Therapeutic-Chemical classification and defined daily dose (ATC/DDD) methodology was used for the first time in Iran. The number of systemic antiinfectives (J class) prescribed for inpatients over a period of 6 months was converted to DDDs. DDD per 100 bed-days was used as a quantitative indicator, and the expenditure share of these drugs was computed. Data were compared with those of similar studies in other countries.
Total prescription of systemic antiinfectives was 101.92 DDD/100 bed-days, of which 62% related to parenteral forms. 58% to broad-spectrum agents, and 40.2% to broad-spectrum parenteral agents. The five most commonly used drugs were ampicillin, cefazolin, ceftizoxime, gentamicin, and cefalexin. Antiinfectives prescribed for inpatients accounted for 25.2% of total drug sales of the hospital pharmacy. Most prescriptions occurred in infectious diseases ward. followed by the intensive care unit, gynecology, obstetrics, and ear-nose-throat wards.
Prescribing patterns in different wards, relationships between use and cost. and monthly variations are identified and discussed. High utilization rate and irrational prescription of antiinfectives in BH, along with inadequate hospital and national drug policies may be concluded from this study. Drug utilization research study is a useful tool to highlight patterns of drug use.
采用标准化方法调查布阿利教学医院（BH）全身抗感染药物的使用模式。
为进行一项标准化且可重复的研究，伊朗首次使用解剖-治疗-化学分类及限定日剂量（ATC/DDD）方法。将6个月期间住院患者开具的全身抗感染药物（J类）数量换算为限定日剂量数。每100床日的限定日剂量数用作定量指标，并计算这些药物的支出占比。将数据与其他国家类似研究的数据进行比较。
全身抗感染药物的总处方量为101.92限定日剂量/100床日，其中62%为注射剂型，58%为广谱药物，40.2%为广谱注射药物。五种最常用的药物为氨苄西林、头孢唑林、头孢唑肟、庆大霉素和头孢氨苄。住院患者开具的抗感染药物占医院药房药品销售总额的25.2%。大多数处方出现在传染病病房，其次是重症监护病房、妇科、产科和耳鼻喉科病房。
确定并讨论了不同病房的处方模式、使用与成本之间的关系以及月度变化情况。本研究可能得出结论，BH医院抗感染药物利用率高且处方不合理，同时医院和国家药品政策也不完善。药物利用研究是突出药物使用模式的有用工具。
