Gromeier M, Wimmer E
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Curr Opin Mol Ther. 2001 Oct;3(5):503-8.
Viruses have been considered for use as therapeutic agents against cancer, and malignant glioma in particular. Oncolytic viruses were designed to target malignant cells supporting efficient virus replication, or rendered vulnerable to viral destruction due to tumor-specific defects in their defense against virus infection. Other than conventional cancer chemotherapy, viral antineoplastic agents require complex interactions with the host organism to reach their target and to unleash their oncolytic activity. Recent progress in the design and therapeutic application of oncolytic viruses carries the promise to make these agents available for treatment of malignant glioma.
病毒已被考虑用作抗癌治疗剂，尤其是针对恶性胶质瘤。溶瘤病毒旨在靶向支持高效病毒复制的恶性细胞，或者由于其抗病毒感染防御中的肿瘤特异性缺陷而易于受到病毒破坏。除了传统的癌症化疗外，病毒抗肿瘤剂需要与宿主生物体进行复杂的相互作用才能到达其靶点并发挥其溶瘤活性。溶瘤病毒在设计和治疗应用方面的最新进展有望使这些药物可用于治疗恶性胶质瘤。
