Mehta M, Rahmani O, Dietzek A M, Mecenas J, Scher L A, Friedman S G, Safa T, Ohki T, Veith F J
Division of Vascular Surgery, Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA.
J Vasc Surg. 2001 Nov;34(5):839-45. doi: 10.1067/mva.2001.118817.
The incidence of postoperative hypertension (HTN) after eversion carotid endarterectomy (e-CEA) was compared with that after standard carotid endarterectomy (s-CEA).
In a retrospective analysis from January 1998 to January 2000, 217 patients underwent 219 CEAs for symptomatic (68) or asymptomatic (151) high-grade (>80%) carotid artery stenosis by either standard (137) or eversion (82) techniques. The eversion technique involves an oblique transection of the internal carotid artery at the carotid bulb and a subsequent endarterectomy by everting the internal carotid artery over the atheromatous plaque. All procedures were done under general anesthesia, and somatosensory-evoked potentials were used for cerebral monitoring. Patients with s-CEA were compared with those with e-CEA for postoperative hemodynamic instability, carotid sinus nerve block, requirement for intravenous vasodilators or vasopressors, stroke, and death.
Patients who underwent e-CEA had a significantly (P <.005) increased postoperative blood pressure and required more frequent intravenous antihypertensive medication (24%), compared with patients having an s-CEA (6%). Furthermore, postoperative vasopressors were required after 10% of s-CEAs, but after none of the e-CEAs. No statistically significant difference was noted in the morbidity or mortality of patients after s-CEA and e-CEA.
e-CEA is a substantial risk factor for HTN in the immediate postoperative period, when compared with the s-CEA. This difference would be even more remarkable in the absence of antihypertensive medications in the e-CEA group and vasopressors in the s-CEA group. Therefore, particular attention should be focused on diagnosing and controlling postoperative HTN in patients after e-CEA.
比较外翻式颈动脉内膜切除术(e-CEA)与标准颈动脉内膜切除术(s-CEA)术后高血压(HTN)的发生率。
在一项回顾性分析中,1998年1月至2000年1月期间,217例患者因有症状(68例)或无症状(151例)的重度(>80%)颈动脉狭窄接受了219次颈动脉内膜切除术,手术采用标准(137例)或外翻(82例)技术。外翻技术包括在颈动脉球部斜行横断颈内动脉,随后将颈内动脉外翻于粥样斑块上进行内膜切除术。所有手术均在全身麻醉下进行,并使用体感诱发电位进行脑功能监测。将接受s-CEA的患者与接受e-CEA的患者在术后血流动力学不稳定、颈动脉窦神经阻滞、静脉使用血管扩张剂或血管升压药的需求、卒中及死亡情况方面进行比较。
与接受s-CEA的患者(6%)相比,接受e-CEA的患者术后血压显著升高(P<.005),且需要更频繁地静脉使用抗高血压药物(24%)。此外,10%的s-CEA术后需要使用血管升压药,而e-CEA术后无一例需要使用。s-CEA和e-CEA术后患者的发病率和死亡率无统计学显著差异。
与s-CEA相比,e-CEA是术后即刻发生HTN的一个重要危险因素。若e-CEA组不使用抗高血压药物而s-CEA组不使用血管升压药,这种差异会更加显著。因此,应特别关注e-CEA术后患者术后HTN的诊断和控制。