Bruce A S, Mainstone J C, Golding T R
Victorian College of Optometry, University of Melbourne, Carlton, Victoria, Australia.
Biomaterials. 2001 Dec;22(24):3249-56. doi: 10.1016/s0142-9612(01)00162-4.
There is a need to understand better the biomaterial characteristics responsible for tear film stability during hydrogel lens wear. The underlying cause of pre-lens tear film instability may be indicated by the distribution of sites of breakup. The purpose of this study was to compare the distribution of rupture sites during wear of a common biomaterial to that without lenses.
A videokeratography unit, the Topographic Modeling System, was used to capture an image of the tear film at the moment of breakup. Forty measurements were made for each of ten subjects, and the resultant rupture site distributions evaluated. The pre-lens tear film breakup locations were studied for Acuvue (Etafilcon A) disposable contact lenses using the same technique.
There was a statistically significant trend for pre-corneal tear film breaks to occur more commonly in parameniscal zones than in areas overlying the central cornea (ANOVA, p = 0.002). With the Etafilcon A lenses, a significant difference in breakup frequency between the two regions was not observed.
The pre-corneal tear film findings are consistent with the meniscus model of tear film stability; however, the biomaterial surface characteristics of Etafilcon A give other factors a more dominant role in tear film rupture.
有必要更好地了解在水凝胶镜片佩戴过程中影响泪膜稳定性的生物材料特性。镜片前泪膜不稳定的根本原因可能由破裂部位的分布显示出来。本研究的目的是比较一种常见生物材料在佩戴过程中与不佩戴镜片时破裂部位的分布情况。
使用一种角膜地形图仪，即地形建模系统，在泪膜破裂瞬间捕捉其图像。对10名受试者每人进行40次测量，并对所得的破裂部位分布进行评估。使用相同技术研究了爱尔康（依他氟康A）一次性隐形眼镜的镜片前泪膜破裂位置。
角膜前泪膜破裂在半月板区比覆盖中央角膜的区域更常见，这一趋势具有统计学意义（方差分析，p = 0.002）。对于依他氟康A镜片，未观察到这两个区域之间的破裂频率有显著差异。
角膜前泪膜的研究结果与泪膜稳定性的半月板模型一致；然而，依他氟康A的生物材料表面特性在泪膜破裂中使其他因素起更主导的作用。
