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器官培养中烟草烟雾毒性的评估。II. 胎兔气管上皮对短期暴露于全烟雾的即时反应的超微结构研究。

The assessment of tobacco smoke toxicity in organ culture. II. Ultrastructural studies on the immediate response of foetal rabbit tracheal epithelium to short-term exposures of whole smoke.

作者信息

Davies P, Kistler G S

出版信息

Experientia. 1975 Jun 15;31(6):682-4. doi: 10.1007/BF01944626.

DOI:10.1007/BF01944626
PMID:1170087
Abstract

Foetal rabbit tracheal organ cultures were exposed under defined conditions to whole cigarette smoke and fixed immediately for electron microscopy. After an exposure to 4 or 8 puffs, epithelial intercellular spaces were enlarged, the apical portion of many cells bulged out into the lumen and many cilia were swollen. An exposure to 12 puffs produced a breakdown of the epithelium.

摘要

将胎兔气管器官培养物在特定条件下暴露于完整香烟烟雾中，然后立即固定以进行电子显微镜检查。暴露于4或8口烟雾后，上皮细胞间隙增大，许多细胞的顶端部分向管腔内突出，许多纤毛肿胀。暴露于12口烟雾后，上皮发生破坏。

相似文献

1
The assessment of tobacco smoke toxicity in organ culture. II. Ultrastructural studies on the immediate response of foetal rabbit tracheal epithelium to short-term exposures of whole smoke.器官培养中烟草烟雾毒性的评估。II. 胎兔气管上皮对短期暴露于全烟雾的即时反应的超微结构研究。
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Arch Environ Health. 1970 Nov;21(5):633-4. doi: 10.1080/00039896.1970.10667307.

引用本文的文献

1
Tracheal epithelium in culture: a model for toxicity testing of inhaled molecules.
Cell Biol Toxicol. 1992 Jul-Sep;8(3):141-50. doi: 10.1007/BF00130521.
2
Organ culture of adult rat and mouse tracheal epithelium: I. Ultrastructure following various culture periods.
Cell Tissue Res. 1976 Jan 27;165(3):371-82. doi: 10.1007/BF00222440.

本文引用的文献

1
The development of the trachea in the rabbit, with particular reference to its fine structure.家兔气管的发育，尤其涉及其精细结构
Anat Anz. 1961 Dec 5;110:214-23.
2
In vivo and in vitro ciliotoxic effects of tobacco smoke.烟草烟雾的体内和体外纤毛毒性作用
Arch Environ Health. 1970 Nov;21(5):633-4. doi: 10.1080/00039896.1970.10667307.
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Chemical and physical factors affecting mammalian ciliary activity.
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Electron microscopic observations of the bronchial epithelium of dogs. II. Smoking dogs.犬支气管上皮的电子显微镜观察。II. 吸烟犬
Exp Mol Pathol. 1968 Dec;9(3):380-99. doi: 10.1016/0014-4800(68)90027-0.
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Penetration of the respiratory epithelium of guinea pigs following exposure to cigarette smoke.暴露于香烟烟雾后豚鼠呼吸道上皮的穿透情况。
Lab Invest. 1974 Jul;31(1):75-81.
6
The assessment of tobacco smoke toxicity in tissue and organ culture: an in vitro arrangement for exposure under defined conditions.组织和器官培养中烟草烟雾毒性的评估：一种在特定条件下进行暴露的体外实验设置。
Experientia. 1974 Apr 15;30(4):436-8. doi: 10.1007/BF01921709.
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Use of nonimmersed in vitro chicken tracheal preparation for the study of ciliary transport activity. Cigarette smoke and related components.
Arch Environ Health. 1970 Mar;20(3):318-25. doi: 10.1080/00039896.1970.10665599.
8
The localization of succinic dehydrogenase, cytochrome oxidase and adenosine triphosphatase in ciliated respiratory epithelium.琥珀酸脱氢酶、细胞色素氧化酶和三磷酸腺苷酶在纤毛呼吸上皮中的定位
J Histochem Cytochem. 1965 Nov-Dec;13(8):677-83. doi: 10.1177/13.8.677.