Chen A F, Samy R N, Gantz B J
Department of Otolaryngology-Head and Neck Surgery, The University of Iowa, Iowa City, USA.
Arch Otolaryngol Head Neck Surg. 2001 Nov;127(11):1385-9. doi: 10.1001/archotol.127.11.1385.
Tumors found in the cerebellopontine angle are predominantly vestibular schwannomas. Mixed tumors found within the cerebellopontine angle are thought to be exceedingly rare and exclusively associated with neurofibromatosis 2. We report a case of a mixed tumor composed of Schwann and meningeal cell proliferations in a patient who was not diagnosed as having neurofibromatosis 2. Mixed tumors composed of neoplastic Schwann and meningeal cells have rarely been reported. However, new evidence indicates that these mixed tumors may be more common than was previously thought and may have an interrelated mechanism of pathogenesis. Although the case we describe does not fulfill the current diagnostic criteria for neurofibromatosis 2, a presumptive diagnosis was given, suggesting that the current diagnostic criteria for neurofibromatosis 2 may be too narrow.
桥小脑角发现的肿瘤主要是前庭神经鞘瘤。桥小脑角内发现的混合性肿瘤被认为极其罕见，且仅与2型神经纤维瘤病相关。我们报告一例由施万细胞和脑膜细胞增生组成的混合性肿瘤病例，该患者未被诊断为2型神经纤维瘤病。由肿瘤性施万细胞和脑膜细胞组成的混合性肿瘤鲜有报道。然而，新证据表明这些混合性肿瘤可能比之前认为的更常见，且可能有相互关联的发病机制。尽管我们描述的病例不符合目前2型神经纤维瘤病的诊断标准，但仍给出了初步诊断，这表明目前2型神经纤维瘤病的诊断标准可能过于狭窄。
