脑室内注射fusaric acid可减轻新生雏鸡中胰高血糖素样肽-1引起的厌食症。

Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick.

作者信息

Bungo T, Kawakami S I, Ohgushi A, Sashihara K, Saito N, Sugahara K, Hasegawa S, Denbow D M, Furuse M

机构信息

Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.

出版信息

Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):251-5. doi: 10.1016/s0091-3057(01)00613-x.

DOI:10.1016/s0091-3057(01)00613-x

PMID:11701195

Abstract

It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-beta-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

摘要

已知向大鼠和雏鸡中枢注射胰高血糖素样肽-1（GLP-1）可抑制进食，但GLP-1的相关系统，尤其是关于雏鸡的，仍有待深入研究。本研究旨在确定去甲肾上腺素能机制是否参与GLP-1对新生雏鸡的厌食作用。向雏鸡中枢给予去甲肾上腺素（NE）可抑制食物摄入，作用与GLP-1导致的发作性睡病相似。然而，尽管多巴胺（DA）不影响食物摄入，但同时给予多巴胺-β-羟化酶（DBH）抑制剂富马酸（FA）可减弱GLP-1对进食行为的抑制作用。这表明新生雏鸡的GLP-1与去甲肾上腺素能系统之间可能存在相互作用关系。