Bungo T, Shimojo M, Masuda Y, Choi Y H, Denbow D M, Furuse M
Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Brain Res. 1999 May 1;826(2):313-6. doi: 10.1016/s0006-8993(99)01299-8.
To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an alpha2-receptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)-beta-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON induced a narcoleptic response and reduced food intake, food intake at 30 min post-injection was enhanced by lower doses (25 and 50 ng) of CLON. Central administration of FA (25, 50 and 100 microg) increased food intake in a dose-dependent fashion. It is suggested that feeding behavior is stimulated by low levels of CLON and decreased by further production of norepinephrine (NE), and FA may play the disturbance of sleeping and then enhance food intake.
为了阐明去甲肾上腺素能系统对新生雏鸡食物摄入的影响，我们研究了脑室内注射α2受体激动剂可乐定（CLON）和多巴胺（DA）-β-羟化酶（DBH）抑制剂富马酸（5-丁基吡啶甲酸）（FA）的作用。虽然高剂量（250 ng）的CLON会引发发作性睡病反应并减少食物摄入量，但较低剂量（25和50 ng）的CLON会增加注射后30分钟时的食物摄入量。中枢给予FA（25、50和100μg）会以剂量依赖的方式增加食物摄入量。这表明低水平的CLON会刺激摄食行为，而去甲肾上腺素（NE）的进一步产生会使其减少，并且FA可能会干扰睡眠进而增加食物摄入量。
