Watanabe K, Negoro T, Okumura A
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan.
Brain Dev. 2001 Nov;23(7):453-66. doi: 10.1016/s0387-7604(01)00274-1.
Epileptic spasms in West syndrome consist of a brief phasic contraction followed by a gradually relaxing tonic component, associated with typical ictal electroencephalographic (EEG) patterns. Three different EEG patterns are associated with a clinical spasm: fast wave bursts, high voltage slow waves (HVS), and desynchronization, occurring in this order. HVS are consistently seen and correspond to a clinical spasm, but usually preceded by fast wave bursts, which may be associated with an inhibition of muscle activity. Epileptic spasms can be classified into: symmetric spasms, asymmetric/asynchronous spasms, focal spasms, spasms with partial seizures, subtle spasms, spasms preceded by brief atonia, or subclinical spasms. Although clinical spasms are usually symmetric, ictal fast waves are always localized, and the following slow waves are not bilaterally synchronous and generalized, suggesting a focal cortical origin of spasms.
韦斯特综合征中的癫痫性痉挛由短暂的阶段性收缩和随后逐渐放松的强直性成分组成，与典型的发作期脑电图（EEG）模式相关。三种不同的EEG模式与临床痉挛相关：快波爆发、高电压慢波（HVS）和去同步化，按此顺序出现。HVS始终可见且与临床痉挛相对应，但通常之前有快波爆发，这可能与肌肉活动的抑制有关。癫痫性痉挛可分为：对称性痉挛、不对称/不同步性痉挛、局灶性痉挛、伴有部分性发作的痉挛、细微痉挛、短暂失张力发作前的痉挛或亚临床痉挛。虽然临床痉挛通常是对称的，但发作期快波总是局限的，随后的慢波并非双侧同步且广泛存在，提示痉挛起源于局灶性皮质。
