Gladman D D, Farewell V T, Rahman P, Schentag C T, Pellett F, Ng C M, Wade J A
University of Toronto, Toronto, Canada.
Hum Immunol. 2001 Nov;62(11):1239-44. doi: 10.1016/s0198-8859(01)00337-8.
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis usually seronegative for rheumatoid factor. An increased frequency of HLA-DR4 has been noted in PsA, particularly among patients with a rheumatoid arthritis like (RA) arthritis. The aim of the current investigation was to compare HLA-DRB104 alleles in patients with PsA, patients with RA, and healthy controls. Sample size calculations based on the frequency of HLA-DR4 suggested that 90 individuals in each patient group would be sufficient to address our question. Therefore, 90 HLA-DRB104 positive patients from each patient group underwent high resolution molecular typing and were included in this study. Although HLA-DRB10401 was the most frequent allele in all groups, its frequency among the PsA patients was lower than that of RA patients and controls. HLA-DRB10402 was higher among patients with PsA. Patients with RA were more likely to have more than one shared epitope allele than either PsA or the healthy control group. HLA-DQB1 alleles did not contribute further information. We suggest that the differences in the class II HLA epitope(s) may also be related to interaction specificity with another molecule functioning in the immune response to a putative arthritogenic antigen and result in differences in disease expression.
银屑病关节炎（PsA）是一种与银屑病相关的炎性关节炎，类风湿因子通常呈血清阴性。PsA患者中HLA - DR4的频率增加，尤其是在类风湿关节炎样（RA）关节炎患者中。本研究的目的是比较PsA患者、RA患者和健康对照者的HLA - DRB104等位基因。基于HLA - DR4频率的样本量计算表明，每个患者组90名个体足以解决我们的问题。因此，来自每个患者组的90名HLA - DRB104阳性患者接受了高分辨率分子分型并纳入本研究。虽然HLA - DRB10401在所有组中是最常见的等位基因，但其在PsA患者中的频率低于RA患者和对照组。HLA - DRB10402在PsA患者中频率更高。与PsA组或健康对照组相比，RA患者更有可能拥有多个共享表位等位基因。HLA - DQB1等位基因未提供更多信息。我们认为，II类HLA表位的差异可能也与在对假定的致关节炎抗原的免疫反应中起作用的另一种分子的相互作用特异性有关，并导致疾病表现的差异。
