Domański E, Przekop F, Skubiszewski B, Wolińska E
Neuroendocrinology. 1975;17(3):265-73. doi: 10.1159/000122362.
Serotonin or melatonin was infused into the 3rd cerebral ventricle (3rd V) or into the medial basal hypothalamus (MBH) of both intact ewes and ewes with lesions of the anterior hypothalamic area (AHA). Prolongation of the estrous cycle and delay of ovulation were obtained after infusions of melatonin or serotonin in both the intact and lesioned ewes. Statistically, serotonin proved to be more effective in this respect than melatonin in the intact ewes. The infusions also blocked the prevulatory peak of LH. Furthermore, the infusion of serotonin blocked estrous behavior, while that of melatonin did not affect this function. The effect of indoleamine infusions in the lesioned ewes, in which the inhibitory action of the AHA over the transmission of gonadotrophic releasing hormones (G-RH) had been eliminated, seems to indicate that the inhibitory action of indoleamines on the release of these neurohormones is being displayed at the level of the MBH.
将血清素或褪黑素注入完整母羊以及下丘脑前部区域（AHA）受损母羊的第三脑室（3rd V）或内侧基底部下丘脑（MBH）。在完整母羊和受损母羊中注入褪黑素或血清素后，发情周期延长且排卵延迟。从统计学角度来看，在这方面血清素在完整母羊中比褪黑素更有效。注入还阻断了促黄体生成素（LH）的排卵前峰值。此外，血清素的注入阻断了发情行为，而褪黑素的注入并未影响此功能。在AHA对促性腺激素释放激素（G-RH）传递的抑制作用已被消除的受损母羊中，吲哚胺注入的效果似乎表明吲哚胺对这些神经激素释放的抑制作用是在MBH水平发挥的。
