Korman N J
Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA.
Dermatol Clin. 2001 Oct;19(4):637-48, viii. doi: 10.1016/s0733-8635(05)70305-3.
The autoimmune blistering diseases are a fascinating group of diseases characterized by the presence of blisters involving the skin and mucous membranes. Understanding of the diagnosis, pathophysiology, and advances in treatment of these diseases has grown enormously in recent years. In this article, the author discusses the major clinical and immunopathologic findings in bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, linea IgA bullous disease, and pemphigus. The article focuses on the therapeutic management of patients with autoimmune blistering diseases, including the appropriate treatment of patients, with particular emphasis on the use of immunomodulating and immunosuppresive agents.
自身免疫性水疱病是一类引人关注的疾病，其特征为皮肤和黏膜出现水疱。近年来，对这些疾病的诊断、病理生理学及治疗进展的认识有了极大提高。在本文中，作者讨论了大疱性类天疱疮、黏膜类天疱疮、获得性大疱性表皮松解症、线状IgA大疱病和天疱疮的主要临床及免疫病理表现。本文重点关注自身免疫性水疱病患者的治疗管理，包括对患者的恰当治疗，尤其强调免疫调节和免疫抑制药物的使用。
