克氏锥虫脱落急性期抗原重复单元中的多个重叠表位增强了其免疫原性。
Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties.
作者信息
Alvarez P, Leguizamón M S, Buscaglia C A, Pitcovsky T A, Campetella O
机构信息
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martin, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
出版信息
Infect Immun. 2001 Dec;69(12):7946-9. doi: 10.1128/IAI.69.12.7946-7949.2001.
Abstract
The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity.
摘要
通过斑点肽和噬菌体展示策略对克氏锥虫的重复性脱落急性期抗原（SAPA）进行了全面定位，结果表明单个SAPA重复序列由多个重叠的B细胞表位组成。我们提出，这种复杂的抗原结构构成了一种重复性的替代机制，以提高其免疫原性。
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