反式-藏红花酸钠可在失血性休克后恢复血压、心率和血浆乳酸水平。
Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock.
作者信息
Giassi L J, Gilchrist M J, Graham M C, Gainer J L
机构信息
Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904-4741, USA.
出版信息
J Trauma. 2001 Nov;51(5):932-8. doi: 10.1097/00005373-200111000-00018.
BACKGROUND
Trans-sodium crocetinate (TSC) has been shown to increase oxygen consumption during hemorrhagic shock. The current study was done to determine the effect of TSC on other parameters such as blood pressure, heart rate, blood pH, and lactate.
METHODS
A rat model of hemorrhagic shock was used, in which a constant volume of blood is removed.
RESULTS
TSC increased mean arterial blood pressure from a value (immediately after hemorrhage) of 35 mm Hg to a value of 75 mm Hg, and all treated animals survived. In contrast, blood pressure in control animals decreased, with most dying soon after the hemorrhage. TSC also lessened the tachycardia which resulted from the hemorrhage. Blood pH did not decrease as much when TSC was given, and plasma lactate levels were greatly reduced.
CONCLUSION
It would appear that TSC is a promising initial treatment for hemorrhagic shock.
背景
反式-藏红花酸钠（TSC）已被证明可增加失血性休克期间的耗氧量。本研究旨在确定TSC对其他参数的影响，如血压、心率、血液pH值和乳酸。
方法
使用失血性休克大鼠模型，其中抽取恒定体积的血液。
结果
TSC使平均动脉血压从（出血后立即）35毫米汞柱升至75毫米汞柱，所有接受治疗的动物均存活。相比之下，对照动物的血压下降，大多数在出血后不久死亡。TSC还减轻了出血引起的心动过速。给予TSC时，血液pH值下降幅度较小，血浆乳酸水平大幅降低。
结论
看来TSC是失血性休克一种有前景的初始治疗方法。
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