解偶联蛋白3的生物学活性。

Uncoupling protein 3 biological activity.

作者信息

Giacobino J P

机构信息

Département de Biochimie Médicale, Centre Médical Universitaire, CH-1211 Genève 4, Switzerland.

出版信息

Biochem Soc Trans. 2001 Nov;29(Pt 6):774-7. doi: 10.1042/0300-5127:0290774.

DOI:10.1042/0300-5127:0290774

PMID:11709073

Abstract

The hypothesis that uncoupling protein 3 (UCP3) is an uncoupling protein involved in heat dissipation is not unequivocally supported. An update of in vitro, ex vivo and in vivo studies testing this hypothesis is presented. Data are provided showing that exercise induces a fatty acid-dependent increase in muscle UCP3 mRNA in humans. The proposed positive correlation between glycolytic capacity and UCP3 level in various muscle-fibre types in the mouse is reassessed. Finally, an association between an intronic polymorphism of UCP3 and adiposity is reported.

摘要

解偶联蛋白3（UCP3）是参与散热的解偶联蛋白这一假说并未得到明确支持。本文对验证该假说的体外、离体及体内研究进展进行了综述。文中提供的数据表明，运动可使人体肌肉中UCP3 mRNA呈脂肪酸依赖性增加。重新评估了小鼠不同肌纤维类型中糖酵解能力与UCP3水平之间推测的正相关关系。最后，报告了UCP3内含子多态性与肥胖之间的关联。