Falgarone G, Dougados M
René Descartes University, Cochin Hospital, Rheumatology B Department, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.
Curr Rheumatol Rep. 2001 Dec;3(6):479-83. doi: 10.1007/s11926-001-0061-y.
This paper reviews the most recent clinical and experimental studies on diacerein, both of which are under investigation. Diacerein could be a disease-modulating agent in osteoarthritis because structural benefits have been reported in recent trials. Moreover, after an empirical use, studies return to the experimental field to understand the mechanism of action of this molecule. However, clinical trials using new sets of criteria could be conducted to estimate the structural modulating effect of diacerein; experimental studies must be performed to understand this effect.
本文综述了关于双醋瑞因的最新临床和实验研究，这两项研究均在进行中。双醋瑞因可能是骨关节炎的一种病情缓解剂，因为近期试验已报道其具有结构改善作用。此外，在经验性应用之后，研究又回到实验领域以了解该分子的作用机制。然而，可以采用新的标准进行临床试验来评估双醋瑞因的结构调节作用；必须开展实验研究以了解这种作用。
