受调控的膜内蛋白水解出现了新变化。
Regulated intramembrane proteolysis takes another twist.
作者信息
Huppert S, Kopan R
机构信息
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Dev Cell. 2001 Nov;1(5):590-2. doi: 10.1016/s1534-5807(01)00081-8.
Abstract
Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.
摘要
菱形蛋白是一种具有七个跨膜结构域的蛋白质，遗传学研究表明它可通过类转化生长因子α配体“斯皮茨”增强表皮生长因子受体（EGFR）信号传导。在此，我们讨论最近发表的论文，这些论文将菱形蛋白鉴定为一种新型丝氨酸蛋白酶，可在其跨膜结构域内切割“斯皮茨”。
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