Oinuma K, Harada Y, Nawata Y, Takabayashi K, Abe I, Kamikawa K, Moriya H
Department of Orthopaedic Surgery, Chiba University School of Medicine, Japan.
Ann Rheum Dis. 2001 Dec;60(12):1145-8. doi: 10.1136/ard.60.12.1145.
To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE).
72 patients with active SLE, who received high dose corticosteroid for the first time, for the development of ON at hips and knees were monitored by magnetic resonance imaging for at least 12 months.
ON lesions were detected in 32/72 patients (44%) between one and five months (3.1 months on average) after starting high dose corticosteroid treatment. No osteonecrotic lesion was newly detected from the sixth month of treatment until the end of the follow up period.
The findings suggested that the actual time of onset of ON in SLE is within the first month of high dose corticosteroid treatment.
研究系统性红斑狼疮（SLE）患者在接受大剂量糖皮质激素治疗后骨坏死（ON）的实际发病时间。
72例首次接受大剂量糖皮质激素治疗的活动性SLE患者，通过磁共振成像对髋部和膝部ON的发生情况进行至少12个月的监测。
在开始大剂量糖皮质激素治疗后的1至5个月（平均3.1个月）内，72例患者中有32例（44%）检测到ON病变。从治疗的第6个月直至随访期结束，未新检测到骨坏死病变。
研究结果表明，SLE患者ON的实际发病时间在大剂量糖皮质激素治疗的第一个月内。
