Peebles R S, Hashimoto K, Collins R D, Jarzecka K, Furlong J, Mitchell D B, Sheller J R, Graham B S
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
J Infect Dis. 2001 Dec 1;184(11):1374-9. doi: 10.1086/324429. Epub 2001 Nov 13.
Severe respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans have been inconclusive. By use of a well-characterized murine model of RSV infection and allergic sensitization with ovalbumin, the effect of a preceding severe RSV infection on the development of the pulmonary allergic inflammatory response and airway hyperresponsiveness (AHR) was tested. The impact of prior allergic sensitization on RSV-induced illness, as measured by weight loss, also was evaluated. RSV infection before allergic sensitization decreased allergen-induced AHR, production of interleukin-13 in lung tissue, and lung eosinophilia. In contrast, allergic sensitization before RSV infection increased AHR and decreased RSV-related weight loss and lung levels of interferon-gamma but did not alter viral clearance. These data provide evidence that RSV-associated AHR occurs in hosts with allergic responses and that allergic inflammation is diminished when preceded by RSV infection.
严重呼吸道合胞病毒（RSV）感染被认为是过敏和哮喘发生的一个风险因素，但人体流行病学研究尚无定论。通过使用特征明确的RSV感染和卵清蛋白过敏性致敏小鼠模型，测试了先前严重RSV感染对肺部过敏性炎症反应和气道高反应性（AHR）发展的影响。还评估了先前过敏性致敏对RSV诱导疾病的影响（通过体重减轻来衡量）。在过敏性致敏之前进行RSV感染可降低过敏原诱导的AHR、肺组织中白细胞介素-13的产生以及肺嗜酸性粒细胞增多。相比之下，在RSV感染之前进行过敏性致敏会增加AHR，并减少与RSV相关的体重减轻以及肺组织中γ干扰素水平，但不会改变病毒清除率。这些数据证明，RSV相关的AHR发生在有过敏反应的宿主中，并且在RSV感染之前发生时，过敏性炎症会减轻。
