Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report.
作者信息
Tsai J C, Sivak-Callcott J A, Haik B G, Zhang J, McLean I W
机构信息
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
J Glaucoma. 2001 Oct;10(5):411-3. doi: 10.1097/00061198-200110000-00009.
PURPOSE
To report the histopathologic and immunohistochemical findings from the iridectomy specimen of a patient with acquired unilateral iris heterochromia due to latanoprost.
PATIENT AND METHODS
A 45-year-old woman with open-angle glaucoma and unilateral iris heterochromia was evaluated for uncontrolled intraocular pressure increase. Subsequently, the patient underwent trabeculectomy with mitomycin C and an iridectomy specimen was obtained for analysis.
RESULTS
The histopathologic analysis of the iridectomy specimen did not reveal any nuclear atypia, nuclear crowding, or mitotic figures. Immunohistochemical studies showed that the iris melanocytes were negative for HMB45 and S-100, and weakly positive for Melan A.
CONCLUSION
Latanoprost-associated iris color change may exhibit a diffuse, uniform, dark velvet-brown appearance, thereby simulating diffuse iris melanoma. Histopathologic and immunohistochemical analysis confirmed the benign characteristics of the affected iris melanocytes.
Zotero 插件