Shuli S, Yongmei Z, Zhiwei Z, Zhijuan J
Beijing Research Laboratory for Brain Aging, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
Neuroreport. 2001 Oct 29;12(15):3317-9. doi: 10.1097/00001756-200110290-00034.
The objective of this study was to investigate whether changes in Abeta and ERAB exist in the brain of diabetic mice, and to observe the effects of APP17 peptide. The numbers of neurons stained by APP17 peptide Abeta1-40 Abeta1-42 Abeta1-16 and ERAB antibodies in the brain of diabetic mice was increased compared with normal mice. Staining in APP17 peptide-protected mice was similar to normal mice. We conclude that increased Abeta1-42 and ERAB is an important cause of neuronal degeneration in diabetic encephalopathy. APP17 peptide retards neuronal degeneration by regulating the metabolism of Abeta.
本研究的目的是调查糖尿病小鼠大脑中是否存在β淀粉样蛋白（Abeta）和内质网相关β淀粉样前体蛋白（ERAB）的变化，并观察APP17肽的作用。与正常小鼠相比，糖尿病小鼠大脑中被APP17肽、Abeta1-40、Abeta1-42、Abeta1-16和ERAB抗体染色的神经元数量增加。APP17肽保护的小鼠中的染色与正常小鼠相似。我们得出结论，Abeta1-42和ERAB的增加是糖尿病性脑病中神经元变性的重要原因。APP17肽通过调节Abeta的代谢来延缓神经元变性。
