白细胞介素-1在慢性移植物抗宿主反应的Th1型和Th2型相关变体中的作用。
Contribution of interleukin-1 to Th1- and Th2-dependent variants of chronic graft-versus-host reaction.
作者信息
Kozlov V A, Safronova I V, Kudaeva O T, Kolesnikova O P
机构信息
Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2001 Aug;132(2):769-71. doi: 10.1023/a:1013038130199.
Semiallogenic transfer of lymphoid cells from parental DBA/2 strain to (C57Bl/6xDBA/2)F1 hybrids induces two variants of chronic graft-versus-host reaction with predominant activation of donor Th1 or Th2 cells [2] in genetically homologous recipients: first, severe inhibition of the humoral immune response, or second, autoimmune disease (lupus nephritis) against the background of suppressed cell and humoral immunity. These variants of chronic graft-versus-host reaction are characterized by different changes in interleukin-1 level.
将亲代DBA/2品系的淋巴细胞半同种异体转移至（C57Bl/6xDBA/2）F1杂种中，在基因同源的受体中可诱导出两种慢性移植物抗宿主反应变体，其中供体Th1或Th2细胞占主导激活[2]：第一种是体液免疫反应严重受抑，第二种是在细胞免疫和体液免疫受抑的背景下发生自身免疫性疾病（狼疮性肾炎）。这些慢性移植物抗宿主反应变体的特征是白细胞介素-1水平有不同变化。
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