Krishnan B R
Pfizer Central Research, AH Biological Discovery, Groton, CT 06340, USA.
Curr Opin Mol Ther. 1999 Aug;1(4):454-7.
Rheumtatoid arthritis (RA) is a crippling, autoimmune disease, and is characterized by inflammation and destruction of joint tissue. Interleukin-1 (IL-1) has been identified as a key pro-inflammatory cytokine responsible for inflammation. One of the mechanisms of regulation of activity of IL-1 is IL-1 receptor antagonist (IL-1ra)-mediated: IL-1RA competes with IL-1 for binding to the IL-1 receptor. Significant progress has been made in the potential application of IL-1ra gene therapyfor the treatment of arthritis. Various vectors have been tested for the delivery of the IL-1ra gene to the intra-articular region. Recent studies in humans have provided encouraging prospects for IL-1ra-mediated arthritis gene therapy.
类风湿性关节炎（RA）是一种致残性自身免疫性疾病，其特征是关节组织的炎症和破坏。白细胞介素-1（IL-1）已被确定为导致炎症的关键促炎细胞因子。IL-1活性调节的机制之一是由IL-1受体拮抗剂（IL-1ra）介导的：IL-1RA与IL-1竞争结合IL-1受体。IL-1ra基因治疗在关节炎治疗的潜在应用方面已取得重大进展。已对多种载体进行了测试，以将IL-1ra基因递送至关节内区域。最近在人体进行的研究为IL-1ra介导的关节炎基因治疗提供了令人鼓舞的前景。
