鉴定出一类特异性抑制HIV-1逆转录酶的新型核苷家族。
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.
作者信息
Chamorro C, Lobatón E, Bonache M C, De Clercq E, Balzarini J, Velázquez S, San-Félix A, Camarasa M J
机构信息
Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006-Madrid, Spain.
出版信息
Bioorg Med Chem Lett. 2001 Dec 3;11(23):3085-8. doi: 10.1016/s0960-894x(01)00635-7.
Abstract
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
摘要
合成了N-3-苄氧羰基甲基和N-3-羧甲基-TBDMS取代的核苷，并评估了它们对HIV复制的活性。发现N-3-羧甲基-TBDMS取代的核苷是HIV-1复制的特异性抑制剂。它们应被视为一类新型且独特的非核苷类逆转录酶抑制剂（NNRTIs）的成员。
Zotero 插件