Santori F R, Brown S M, Lu Y, Neubert T A, Vukmanovic S
Michael Heidelberger Division of Immunology, Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
J Immunol. 2001 Dec 1;167(11):6092-5. doi: 10.4049/jimmunol.167.11.6092.
Antagonist-like engagement of the TCR has been proposed to induce T cell selection in the thymus. However, no natural TCR ligand with TCR antagonist activity is presently known. Using a combination of bioinformatics and functional testing we identified the first self-peptide that can both deliver antagonist-like signals and promote T cell selection in the thymus. The peptide is presented by appropriate MHC class I molecules in vivo. Thus, endogenous antagonist peptides exist and may be involved in TCR repertoire selection.
TCR的类似拮抗剂的结合已被提出可诱导胸腺中的T细胞选择。然而，目前尚无具有TCR拮抗剂活性的天然TCR配体。通过生物信息学和功能测试相结合的方法，我们鉴定出了首个既能传递类似拮抗剂的信号又能促进胸腺中T细胞选择的自身肽。该肽在体内由合适的I类MHC分子呈递。因此，内源性拮抗剂肽确实存在，并且可能参与TCR库的选择。
