Costa M A, Silva N C, Castro-Prado M A
Universidade Paranaense, Instituto de Ciências Farmacêuticas e Bioquímica, Praça Mascarenhas de Morais S/N, Umuarama, Paraná, Brasil, 87500-000.
Biol Res. 2001;34(2):91-8. doi: 10.4067/s0716-97602001000200012.
An analysis of a new medusa mutant of Aspergillus nidulans obtained by 5-azacytidine-treatment and named B116 is provided. The B116 mutant was phenotypically characterized by the production of conidiophores with reduced pigmentation and vesicles bearing multiple tiers of sterigmata. A single nuclear gene located on chromosome I is responsible for phenotypical changes in the mutant. The 5-azacytidine-altered locus, designated medA102, is recessive in heterozygous diploid and the medusa mutant is a Dp(II,I) duplication bearer that renders the strain mitotically unstable.
