Brand A, de Bois C H, Vandenhende R
Tijdschr Diergeneeskd. 1975 Feb 15;100(4):191-201.
Parenteral administration of 2.5-5 mg. of prostaglandin F2alpha to horses, 15 mg. to heifers or 25-30 mg to lactating cows and 15 mg. to sheep will induce regression of the corpus luteum (luteolysis) and a fertile oestrus within 48-72 hours. Because of their luteolytic effect prostaglandins may be used in various indications in the field of reproduction. An exception is the pig in which administration of prostaglandins does not induce luteolysis before D12 and therefore fails to induce oestrus. In horses, cattle and sheep, administration of prostaglandins during the first four days of the cycle is ineffective. In the present paper, a few indications for the use of prostaglandins are described, including induction of oestrus (in cases of suboestrus), synchronisation of oestrus, termination of unwanted gestation, elimination of a persistent corpus luteum (purulent endometritis, pyometra, mummified foetus), induction of parturition. In addition, some other indications are listed, such as reduction of the interval between parturition and conception, chronic endometritis, hydroallantois, luteinized cysts and suboestrus post weaning. In the opinion of the present authors, the most important field for the use of prostaglandins will be that of induction and synchronisation of oestrus. As regards the fertility of synchronized oestrus induced by prostaglandins, it is stated that, in cattle and horses, this is superior to that following treatment with progestagen. Extensive field trials will be required to determine whether the fertility of oestrus induced by prostaglandins is equivalent to that following spontaneous oestrus.
给马静脉注射2.5 - 5毫克前列腺素F2α，给小母牛注射15毫克，给泌乳奶牛注射25 - 30毫克，给绵羊注射15毫克，会在48 - 72小时内引起黄体退化（黄体溶解）并出现可受孕的发情期。由于其黄体溶解作用，前列腺素可用于繁殖领域的各种适应症。猪是个例外，在猪中，在第12天之前注射前列腺素不会引起黄体溶解，因此无法诱导发情。在马、牛和羊中，在发情周期的前四天注射前列腺素无效。在本文中，描述了一些使用前列腺素的适应症，包括诱导发情（在发情不足的情况下）、发情同步、终止意外妊娠、消除持续黄体（脓性子宫内膜炎、子宫蓄脓、木乃伊化胎儿）、诱导分娩。此外，还列出了一些其他适应症，如缩短分娩与受孕之间的间隔、慢性子宫内膜炎、羊水过多、黄体化囊肿和断奶后发情不足。本文作者认为，使用前列腺素最重要的领域将是诱导发情和发情同步。关于前列腺素诱导的同步发情的生育力，据称，在牛和马中，这优于用孕激素治疗后的生育力。需要进行广泛的田间试验来确定前列腺素诱导的发情的生育力是否与自然发情后的生育力相当。
