Newsome P N, Bathgate A J, Henderson N C, MacGilchrist A J, Plevris J N, Masterton G, Garden O J, Lee A, Hayes P C, Simpson K J
Lancet. 2001 Nov 10;358(9293):1612-3. doi: 10.1016/S0140-6736(01)06663-6.
Paracetamol overdose is the commonest cause of acute liver failure in the UK, which has led to measures to restrict its sale. We aimed to establish whether changes in the referral of patients with paracetamol-induced acute liver failure have occurred since the introduction of legislation. We compared data from patients admitted to the Scottish Liver Transplantation Unit in 1992-98 with those admitted in 1998-2001. The incidence of paracetamol-induced liver failure, severity of patients' illness, and outcome did not differ between the groups. Patients with paracetamol-induced acute liver failure had higher Carstairs scores (1.99 [95% CI 1.33-2.65]; n=190) than patients with non-paracetamol acute liver failure (0.02 [-0.79 to 0.84]; n=68). We have shown an association between paracetamol-induced acute liver failure and social deprivation.
对乙酰氨基酚过量服用是英国急性肝衰竭最常见的病因，这促使了限制其销售的措施出台。我们旨在确定自立法实施以来，对乙酰氨基酚所致急性肝衰竭患者的转诊情况是否发生了变化。我们比较了1992 - 1998年和1998 - 2001年入住苏格兰肝移植病房患者的数据。两组之间对乙酰氨基酚所致肝衰竭的发生率、患者病情严重程度及转归并无差异。对乙酰氨基酚所致急性肝衰竭患者的卡斯尔斯评分（1.99 [95%可信区间1.33 - 2.65]；n = 190）高于非对乙酰氨基酚所致急性肝衰竭患者（0.02 [-0.79至0.84]；n = 68）。我们已表明对乙酰氨基酚所致急性肝衰竭与社会剥夺之间存在关联。
