Quan C, Guo X
Department of Otolaryngology Head and Neck Surgery, First Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun 130021.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1998 Oct;33(5):273-5.
To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer.
A PCR-PAGE-Laser scanning technique was applied.
There was no Myc gene amplification in the normal laryngeal tissues. The abnormal L-myc and C-myc gene were positive in 47% (15/32) of laryngeal cancers and 41% (13/32) of the cancers shown the N-myc gene amplification. Myc gene amplification was not related to age, sex and differentiation (P > 0.05), but the N-myc amplification was higher in patients with lymph node metastasis (P < 0.05).
The N-myc amplification may play a role of positive regulation in the lymph metastasis of laryngeal cancer. The abnormal amplification of Myc gene family is one of the causes in development of laryngeal cancer.
研究Myc基因家族在喉癌发生发展中的异常扩增及作用。
应用聚合酶链反应-聚丙烯酰胺凝胶电泳-激光扫描技术。
正常喉组织中无Myc基因扩增。异常的L-myc和C-myc基因在47%（15/32）的喉癌中呈阳性，41%（13/32）的癌显示有N-myc基因扩增。Myc基因扩增与年龄、性别及分化无关（P>0.05），但有淋巴结转移患者的N-myc扩增率较高（P<0.05）。
N-myc扩增可能在喉癌的淋巴转移中起正调控作用。Myc基因家族的异常扩增是喉癌发生的原因之一。
