[血管通透性因子在鼻息肉中的表达及意义]
[Expression and significance of vascular permeability factor in nasal polyps].
作者信息
Yang J, Kong H, Dong Z
机构信息
Third Clinical College, Bethune University of Medical Sciences, Changchun 130031.
出版信息
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1998 Oct;33(5):297-8.
OBJECTIVE
To study the expression and significance of vascular permeability factor(VPF) in nasal polyps.
METHODS
Expression of VPF and its receptor flk-1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope.
RESULTS
The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates (P < 0.01 and P < 0.05, respectively). The flk-1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates (P < 0.01).
CONCLUSION
VPF may play a key role in the formation of heavy edema of nasal polyps.
目的
研究血管通透因子（VPF）在鼻息肉中的表达及意义。
方法
采用免疫组织化学方法前瞻性研究9例鼻息肉患者和8例慢性鼻炎患者下鼻甲组织中VPF及其受体flk-1的表达。在光学显微镜下观察各组织切片。
结果
鼻息肉组织中血管内皮细胞和腺细胞的VPF阳性率显著高于下鼻甲组织（分别为P < 0.01和P < 0.05）。鼻息肉组织中血管内皮细胞的flk-1标记指数显著高于下鼻甲组织（P < 0.01）。
结论
VPF可能在鼻息肉重度水肿形成中起关键作用。
Zotero 插件