膜运输：内体分选过程中的泛素化作用
Membrane transport: ubiquitylation in endosomal sorting.
作者信息
Dupré S, Volland C, Haguenauer-Tsapis R
机构信息
Institut Jacques Monod, Universités Paris VI and Paris VII, 2 place Jussieu, 75251 PARIS Cedex 05, France.
出版信息
Curr Biol. 2001 Nov 13;11(22):R932-4. doi: 10.1016/s0960-9822(01)00558-9.
Abstract
In yeast, membrane proteins from the biosynthetic and endocytic pathways must be ubiquitylated for sorting to inward-budding vesicles in late endosomes, which give rise to multivesicular bodies. A conserved protein complex containing the yeast Vps23p or its mammalian counterpart Tsg101 may act as the ubiquitin receptor.
摘要
在酵母中，生物合成途径和内吞途径的膜蛋白必须被泛素化，以便在内体后期被分选到向内出芽的囊泡中，这些囊泡会形成多泡体。一种包含酵母Vps23p或其哺乳动物对应物Tsg101的保守蛋白复合物可能充当泛素受体。
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