Van Laere K J, Dierckx R A
Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Radiology. 2001 Dec;221(3):810-7. doi: 10.1148/radiol.2213010295.
To investigate brain perfusion at single photon emission computed tomography (SPECT) as a function of age and sex in healthy adult volunteers and to correlate perfusion with gray matter concentration determined by using voxel-based morphometry (VBM).
Eighty-one healthy volunteers underwent both technetium 99m ethylene cysteine dimer SPECT and three-dimensional magnetization preparation rapid acquisition gradient-echo magnetic resonance (MR) imaging. Statistical parametric mapping was used to conduct VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of the perfusion data and more specifically in brain areas showing significant perfusion changes.
VBM data, as compared with perfusion changes, indicated a more symmetric age-related gray matter volume decrease along the Sylvian fissure and in subcortical regions (P < .001). The combination of functional and structural changes indicated a relatively lower functional decrease with aging, as compared with the structural atrophy in the visual, parietal, sensorimotor, and right prefrontal cortices. Significant relative morphologic sex-based differences were found in the cerebellar and temporal cortices, but the comparison did not reveal significant differences between the functional and morphometric data.
Age-related perfusion changes are paralleled by similar more symmetric changes in gray matter concentration, which are more prominent than the perfusion changes in some regions. No sex-based differences between perfusion and gray matter concentration were found.
研究健康成年志愿者单光子发射计算机断层扫描（SPECT）脑灌注随年龄和性别的变化，并将灌注与基于体素形态学测量（VBM）确定的灰质浓度进行关联。
81名健康志愿者接受了锝99m乙半胱氨酸二聚体SPECT和三维磁化准备快速采集梯度回波磁共振（MR）成像。使用统计参数映射对形态学数据进行VBM分析，并将其逐体素地与灌注数据的类似分析结果进行比较，更具体地是在显示出显著灌注变化的脑区进行比较。
与灌注变化相比，VBM数据表明沿外侧裂和皮质下区域存在更对称的与年龄相关的灰质体积减少（P <.001）。功能和结构变化的结合表明，与视觉、顶叶、感觉运动和右前额叶皮质的结构萎缩相比，随着年龄增长功能下降相对较小。在小脑和颞叶皮质中发现了基于性别的显著相对形态学差异，但比较未揭示功能和形态测量数据之间的显著差异。
与年龄相关的灌注变化与灰质浓度的类似更对称变化平行，在某些区域灰质浓度变化比灌注变化更明显。未发现灌注和灰质浓度之间存在基于性别的差异。
