Bernard B K, Paolino R M
Physiol Behav. 1975 Feb;14(2):201-6. doi: 10.1016/0031-9384(75)90166-3.
Alterations in shock-induced aggressive behavior, general emotional reactivity and flinch thresholds in 61 and 82 day old male rats were analyzed at either 3 or 6 weeks following castration. Castrated animals were significantly less aggressive than sham-operated controls at the 6 week but not the 3 week interval. These findings could not be attributed to changes in flinch threshold as neither treatment nor time affected this measure. With regard to emotionality, castrated animals were significantly more reactive than the control animals at the 3 week but not 6 week interval. The data are interpreted as indicating that castration altered shock-induced aggression by preventing a maturational increase in such behavior. These behavioral alterations are compared to previously reported time-dependent changes in brain monoaminergic dynamics following gonadectomy. The conclusions support the concept of a necessary balance between catecholaminergic and serotonergic systems with regard to affective behavior.
对61日龄和82日龄雄性大鼠在去势后3周或6周时休克诱导的攻击行为、一般情绪反应性和退缩阈值的变化进行了分析。在6周时，去势动物的攻击性明显低于假手术对照组，但在3周时并非如此。这些发现不能归因于退缩阈值的变化，因为处理和时间都未影响该指标。关于情绪方面，在3周时，去势动物比对照动物的反应性明显更高，但在6周时并非如此。数据被解释为表明去势通过阻止这种行为的成熟性增加而改变了休克诱导的攻击行为。将这些行为变化与先前报道的性腺切除术后大脑单胺能动力学随时间的变化进行了比较。这些结论支持了在情感行为方面儿茶酚胺能系统和血清素能系统之间需要保持平衡的概念。
