Liu Y, Curtis J T, Fowler C D, Spencer C, Houpt T, Wang Z X
Department of Psychology, Neuroscience Program, Florida State University, Tallahassee, FL 32306, USA.
J Neuroendocrinol. 2001 Dec;13(12):1059-65. doi: 10.1046/j.1365-2826.2001.00729.x.
Forced swimming, as an effective stressor, has been found to facilitate the development of pair bonds in male but to interfere with this behaviour in female prairie voles (Microtus ochrogaster). In the present study, we found that forced swimming differentially influenced the expression of messenger RNA for vasopressin, oxytocin and corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) in the prairie vole brain. Forced swimming did not alter vasopressin mRNA labelling, but did induce a sustained decrease in oxytocin mRNA labelling and a progressive increase in CRH mRNA labelling in the PVN. The elevated CRH mRNA labelling appeared to be due to an increased number of cells synthesizing CRH mRNA and an enhanced ability of individual cells to produce CRH mRNA. Male and female prairie voles did not differ in the vasopressin, oxytocin or CRH mRNA expression either at the basal levels or in response to swimming stress. Together, these data indicate that the hypothalamic response of vasopressin, oxytocin and CRH messenger RNAs to swimming stress is regulated by distinct transcriptional factors. In addition, it seems unlikely that these changes are involved directly in the sex differences in pair bond formation.
强迫游泳作为一种有效的应激源，已被发现可促进雄性草原田鼠（Microtus ochrogaster）配偶关系的形成，但会干扰雌性草原田鼠的这种行为。在本研究中，我们发现强迫游泳对草原田鼠大脑下丘脑室旁核（PVN）中加压素、催产素和促肾上腺皮质激素释放激素（CRH）的信使核糖核酸表达有不同影响。强迫游泳并未改变加压素信使核糖核酸标记，但确实导致PVN中催产素信使核糖核酸标记持续减少，CRH信使核糖核酸标记逐渐增加。CRH信使核糖核酸标记升高似乎是由于合成CRH信使核糖核酸的细胞数量增加以及单个细胞产生CRH信使核糖核酸的能力增强。雄性和雌性草原田鼠在基础水平或对游泳应激的反应中，加压素、催产素或CRH信使核糖核酸表达均无差异。总之，这些数据表明，加压素、催产素和CRH信使核糖核酸对游泳应激的下丘脑反应受不同转录因子调控。此外，这些变化似乎不太可能直接参与配偶关系形成中的性别差异。
