Lloyd Granville L., Schaeffer Anthony J.
Northwestern University School of Medicine, Department of Urology, Tarry 11-713, 303 E. Chicago Avenue, Chicago, IL 60611-3008, USA.
Curr Infect Dis Rep. 2001 Dec;3(6):534-539. doi: 10.1007/s11908-001-0091-7.
Prostatitis has long been a poorly understood and poorly characterized entity. Characterized in 1980 as a "wastebasket of clinical ignorance," it has only recently begun to be studied effectively. Prostatitis represents over 2 million medical office visits per year in the United States, and is the diagnosis given to 8% of urology clinic patients. Its prevalence may be as high as 10% among the male population at large. Sufferers report a sickness impact of prostatitis that is similar to myocardial infarction or Crohn's disease. Less than 10% of cases of prostatitis are easily demonstrable to have a bacterial cause; these respond to conventional antimicrobial treatment. The etiology, pathogenesis, and optimum treatment for the remaining 90% of sufferers of this disease complex are quite unclear. Application of clinical research techniques and molecular biology promise new insight into this challenging and difficult problem.
前列腺炎长期以来一直是一个了解甚少且特征不明的病症。1980年它被描述为“临床无知的垃圾桶”,直到最近才开始得到有效研究。在美国,每年因前列腺炎前往医疗机构就诊的人数超过200万,在泌尿科门诊患者中,8%的人被诊断为此病。在广大男性人群中,其患病率可能高达10%。患者报告称,前列腺炎对健康的影响类似于心肌梗死或克罗恩病。不到10%的前列腺炎病例能轻易证明有细菌病因,这些病例对传统抗菌治疗有反应。对于这一复杂病症其余90%的患者,其病因、发病机制和最佳治疗方法仍相当不清楚。临床研究技术和分子生物学的应用有望为这一具有挑战性的难题带来新的见解。