构树属植物成分的研究X. 来自小构树的六种新生物碱

Studies on the constituents of Broussonetia species X. Six new alkaloids from Broussonetia kazinoki Sieb.

作者信息

Tsukamoto D, Shibano M, Kusano G

机构信息

Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2001 Nov;49(11):1487-91. doi: 10.1248/cpb.49.1487.

DOI:10.1248/cpb.49.1487

PMID:11724246

Abstract

Six new alkaloids, broussonetines W, X, M1, U1, J3, and J2 (1-6) were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae) as minor constituents. They were formulated as (2R,3R,4R,5R)-2-hydroxy-methyl-3,4-dihydroxy-5-17-(cyclohexy-2-on-1(6)-enyl)heptyllpyrrolidine (1), (2R,3S,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-17-(cyclohexy-2-on-1(6)-enyl)heptyl]pyrrolidine-4-O-beta-D-glucopyranoside (2), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(9R)-9,13-dihydroxytridecyl]- pyrrolidine (3), (2S,3S,4S)-2-hydroxymethyl-3,4-dihydroxy-5-(10-oxo-13-hydroxytridecyl)-5- pyrroline (4), (2R)-2-[(IS,2S)-1,2-dihydroxy-8-1(2R,3R,4R,5R)-5-(2-hydroxymethyl-3,4-dihydroxy-1-acetylpyrrolidinyl)loctyl]piperidine (5), (2R)-2-[(1S,2S)-1,2-dihydroxy-8-[(2R,3R, 4R,5R)-5-(2-hydroxymethy]-3,4-dihydroxypyrrolidinyl)]octyl]piperidine (6).

摘要

从构棘（桑科）的枝条中分离出6种新生物碱，构棘碱W、X、M1、U1、J3和J2（1-6），为微量成分。它们的结构分别为(2R,3R,4R,5R)-2-羟甲基-3,4-二羟基-5-[17-(环己-2-酮-1(6)-烯基)庚基]吡咯烷（1）、(2R,3S,4R,5R)-2-羟甲基-3,4-二羟基-5-[17-(环己-2-酮-1(6)-烯基)庚基]吡咯烷-4-O-β-D-吡喃葡萄糖苷（2）、(2R,3R,4R,5R)-2-羟甲基-3,4-二羟基-5-[(9R)-9,13-二羟基十三烷基]吡咯烷（3）、(2S,3S,4S)-2-羟甲基-3,4-二羟基-5-(10-氧代-13-羟基十三烷基)-5-吡咯啉（4）、(2R)-2-[(1S,2S)-1,2-二羟基-8-[(2R,3R,4R,5R)-5-(2-羟甲基-3,4-二羟基-1-乙酰基吡咯烷基)辛基]哌啶（5）、(2R)-2-[(1S,2S)-1,2-二羟基-8-[(2R,3R,4R,5R)-5-(2-羟甲基-3,4-二羟基吡咯烷基)]辛基]哌啶（6）。