轮叶沙参（桔梗科）中的多羟基化吡咯烷和哌啶生物碱。

Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae).

作者信息

Asano N, Nishida M, Miyauchi M, Ikeda K, Yamamoto M, Kizu H, Kameda Y, Watson A A, Nash R J, Fleet G W

机构信息

Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

出版信息

Phytochemistry. 2000 Feb;53(3):379-82. doi: 10.1016/s0031-9422(99)00555-5.

DOI:10.1016/s0031-9422(99)00555-5

PMID:10703061

Abstract

Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM).

摘要

轮叶沙参（桔梗科）产生了两种新生物碱，即2R,5R-双（羟甲基）-3R,4R-二羟基吡咯烷（DMDP）的6-C-丁基衍生物和α-1-C-乙基-法戈明，以及已知生物碱1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇、1-脱氧野尻霉素和1-脱氧甘露野尻霉素。6-C-丁基-DMDP对杏仁β-葡萄糖苷酶表现出抑制活性（IC50 = 68微摩尔），而α-1-C-乙基-法戈明抑制牛肝β-半乳糖苷酶（IC50 = 29微摩尔）。