特发性帕金森病的病因
The aetiology of idiopathic Parkinson's disease.
作者信息
Ramsden D B, Parsons R B, Ho S L, Waring R H
机构信息
Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.
出版信息
Mol Pathol. 2001 Dec;54(6):369-80.
Abstract
Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (alpha synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents.
摘要
本文讨论了可能与特发性帕金森病病因相关的因素。这些因素包括调节多巴胺能神经发生的因子（Nurr 1、Ptx - 3和Lmx1b）及相关蛋白，以及与家族性帕金森病相关的基因（α - 突触核蛋白、帕金蛋白和泛素羧基末端水解酶L1），还有内源性和环境因素。
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