Lichtenstein G R
Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
Semin Gastrointest Dis. 2001 Oct;12(4):275-83.
Decreased bone mineral density, osteoporosis, is a common disorder in the United States and elsewhere in the world. This disorder is estimated to account for more than 1.5 million bone fractures each year and is estimated to cost over 13 billion dollars annually. Inflammatory Bowel Disease is a relatively common disorder with estimates suggesting that approximately one million Americans are afflicted by these conditions. Osteoporosis is a common extraintestinal complication of inflammatory bowel disease. The importance of the many possible mechanisms contributing to the loss of bone mass in IBD is uncertain. Several of these specific factors, including the use of corticosteroids, calcium deficiency, vitamin D deficiency, chronically active inflammatory bowel disease, and malnutrition. Assessment of the bone mineral density is an important exercise since new therapeutic options exist and new options are available to combat and even prevent this costly complication.
骨矿物质密度降低,即骨质疏松症,在美国及世界其他地方都是一种常见病症。据估计,这种病症每年导致超过150万例骨折,每年的花费估计超过130亿美元。炎症性肠病是一种相对常见的病症,据估计约有100万美国人受其困扰。骨质疏松症是炎症性肠病常见的肠外并发症。导致炎症性肠病骨量流失的众多可能机制的重要性尚不确定。其中一些具体因素包括使用皮质类固醇、钙缺乏、维生素D缺乏、慢性活动性炎症性肠病和营养不良。评估骨矿物质密度是一项重要工作,因为存在新的治疗选择,并且有新的方法来对抗甚至预防这种代价高昂的并发症。