Szilágyi A, Mánfai Z, Kiesel L, Szabó I
Department of Obstetrics and Gynecology, University of Pécs, 17 Edesanyák st., H-7624 Pécs, Hungary.
Gynecol Endocrinol. 2001 Oct;15(5):325-7.
Kallmann's syndrome is characterized by hypogonadotropic hypogonadism and anosmia. Assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI) may be required to treat the infertile couple with oligozoospermia. Rare complications have been described in patients with Kallmann's syndrome, but gestational diabetes has not previously been reported. A case of Kallmann's syndrome with infertility is reported. Ovulation was successfully induced by human menopausal gonadotropin therapy, but pregnancy could not be achieved by artificial insemination or by conventional in vitro fertilization, although the husband had only moderate oligozoospermia. A high fertilization rate of the retrieved oocytes and successful pregnancy was achieved by ICSI. The pregnancy was complicated by gestational diabetes that was managed by insulin therapy. Successful ovulation induction in Kallmann's syndrome is not rare, but ICSI may be needed in selected cases. Some recent data have suggested that diabetes may occur in patients with Kallmann's syndrome, but further investigation is needed to establish whether gestational diabetes is associated with Kallmann's syndrome or is purely coincidental.
卡尔曼综合征的特征是低促性腺激素性性腺功能减退和嗅觉缺失。对于少精子症的不孕夫妇，可能需要采用胞浆内单精子注射（ICSI）等辅助生殖技术进行治疗。卡尔曼综合征患者曾有罕见并发症的报道，但此前未报告过妊娠期糖尿病。本文报告一例患有不孕症的卡尔曼综合征病例。通过人绝经期促性腺激素治疗成功诱导排卵，但尽管丈夫仅有中度少精子症，人工授精或传统体外受精均未成功受孕。通过ICSI实现了所取卵母细胞的高受精率并成功妊娠。该妊娠合并妊娠期糖尿病，通过胰岛素治疗得以控制。卡尔曼综合征中成功诱导排卵并不罕见，但在某些特定病例中可能需要ICSI。最近的一些数据表明，卡尔曼综合征患者可能会发生糖尿病，但需要进一步研究以确定妊娠期糖尿病与卡尔曼综合征是相关还是纯属巧合。
