Guvenal T, Kantas E, Erselcan T, Culhaoglu Y, Cetin A
Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
Int J Gynaecol Obstet. 2001 Dec;75(3):229-34. doi: 10.1016/s0020-7292(01)00495-7.
To evaluate and to compare the predictive value of cervicovaginal beta-hCG and prolactin levels in spontaneous preterm delivery.
The preterm labor group and normal pregnancy group consisted of 17 and 43 patients between 24 and 36 weeks' gestation, respectively. A single cervicovaginal beta-hCG and prolactin measurement were made in both groups.
Cervicovaginal beta-hCG and prolactin levels were significantly higher in the preterm group when compared with those of the term delivery group (P=0.031, P=0.026, respectively). The optimal cut-off value for beta-hCG (27.1 mIU/ml) gave a sensitivity level of 87.5% (47.4-97.9; 95% C.I.) at a specificity of 65.4% (50.9-78.0; 95% C.I.) with positive and negative predictive values of 28% and 97%, respectively. The optimal cut-off value for prolactin (1.8 ng/ml) gave a sensitivity level of 50% (16.0-84.0; 95% C.I.) at a specificity of 96% (86.8-99.4; 95% C.I.) with positive and negative predictive values of 67% and 93%, respectively.
Cervicovaginal beta-hCG measurement in patients with preterm labor may be used as a predictive test. Cervicovaginal prolactin is not a sensitive test compared with the beta-hCG test.
评估并比较宫颈阴道β - 人绒毛膜促性腺激素（β - hCG）和催乳素水平对自发性早产的预测价值。
早产组和正常妊娠组分别由17例和43例妊娠24至36周的患者组成。两组均进行了单次宫颈阴道β - hCG和催乳素测量。
与足月分娩组相比，早产组的宫颈阴道β - hCG和催乳素水平显著更高（分别为P = 0.031，P = 0.026）。β - hCG的最佳临界值（27.1 mIU/ml）在特异性为65.4%（50.9 - 78.0；95%置信区间）时，敏感性水平为87.5%（47.4 - 97.9；95%置信区间），阳性预测值和阴性预测值分别为28%和97%。催乳素的最佳临界值（1.8 ng/ml）在特异性为96%（从86.8至99.4；95%置信区间）时，敏感性水平为50%（16.0 - 84.0；95%置信区间），阳性预测值和阴性预测值分别为67%和93%。
早产患者的宫颈阴道β - hCG测量可作为一种预测性检测。与β - hCG检测相比宫颈阴道催乳素检测不是一种敏感的检测方法。
