Ochoa R, Zárate A, Hernández M, Galván R, Basurto L
Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Gynecol Obstet Invest. 2001;52(4):243-7. doi: 10.1159/000052983.
To determine whether cord sera leptin and components of the somatotropin axis - growth hormone (GH), total (t) and free (f) insulin-like growth factor (IGF), IGF-binding protein-3 (IGFBP-3), and insulin - correlate with birth weight.
Cross-sectional study of 22 newborns, 12 with normal birth weight (NBW) and 10 with low birth weight (LBW), in a population of healthy mothers with an apparent normal pregnancy.
Paired mother-neonate blood samples were obtained at vaginal delivery in order to measure leptin and the somatotropin axis components.
In all cases maternal blood concentrations of leptin, t and fIGF-I, its carrier protein IGFBP-3, and insulin were higher than in the cord sera of the newborns, regardless of their birth weight. On the contrary, maternal GH levels were lower than in their neonates. LBW neonates had decreased levels of leptin, tIGF-I, and IGFBP-3 as compared with those levels in NBW offspring; however, GH concentrations were higher in LBW neonates. Birth weight showed a significant correlation with cord sera leptin, tIGF-I, IGFBP-3, and GH; nevertheless birth weight was neither interrelated with fIGF-I nor with insulin levels.
These data demonstrate that birth weight is significantly correlated with both leptin and some components of the somatotropin axis; on the other hand, no correlation was observed between leptin concentrations and each one of the components of the somatotropin axis. It is suggested that fetal leptin and the somatotropin axis cooperate in intrauterine growth and birth weight.
确定脐血清瘦素和生长激素轴的组成部分——生长激素（GH）、总（t）和游离（f）胰岛素样生长因子（IGF）、IGF结合蛋白-3（IGFBP-3）以及胰岛素——是否与出生体重相关。
对22名新生儿进行横断面研究，其中12名出生体重正常（NBW），10名出生体重低（LBW），研究对象为妊娠明显正常的健康母亲群体。
在阴道分娩时采集母婴配对血样，以测定瘦素和生长激素轴的组成部分。
在所有情况下，无论新生儿出生体重如何，母亲血液中瘦素、t和fIGF-I、其载体蛋白IGFBP-3以及胰岛素的浓度均高于新生儿脐血清中的浓度。相反，母亲的GH水平低于其新生儿。与NBW后代相比，LBW新生儿的瘦素、tIGF-I和IGFBP-3水平降低；然而，LBW新生儿的GH浓度较高。出生体重与脐血清瘦素、tIGF-I、IGFBP-3和GH显著相关；然而，出生体重与fIGF-I和胰岛素水平均无相关性。
这些数据表明出生体重与瘦素和生长激素轴的某些组成部分显著相关；另一方面，未观察到瘦素浓度与生长激素轴的各个组成部分之间存在相关性。提示胎儿瘦素和生长激素轴在子宫内生长和出生体重方面协同作用。
