Ogata Y, Sasatomi T, Araki Y, Ishibashi N, Nozoe Y, Miyagi Y, Nakagawa M, Matono K, Kishimoto Y, Hayashi A, Mituoka M, Konishi J, Shirouzu K
Dept. of Surgery, Kurume University School of Medicine.
Gan To Kagaku Ryoho. 2001 Nov;28(12):1917-21.
The patient was a 52-year-old woman who had sigmoid colon cancer with liver metastasis and multiple lung metastases. Resection of curability B was performed, and alternating adjuvant chemotherapy consisting of hepatic artery injection of 5-FU and systemic administration of CPT-11 was performed. Lung recurrence was found and no antitumor effect of chemotherapy was observed, so the CPT-11 which had been administered every other week was given every week in a dose of 60 mg/body, half of the original dose. Moreover, 5'-DFUR was administered in a dose of 800 mg/day every day. As a result, lung metastasis tumors were reduced markedly. Adverse events such as nausea, vomiting and depilation were mitigated, and no other toxicity was observed. The patient could thus be treated extremely safely in the outpatient clinic. This was considered to be a valuable case suggestive of the significance of combination chemotherapy of CPT-11 and 5'-DFUR and the importance of appropriate administration of CPT-11.
该患者为一名52岁女性，患有乙状结肠癌伴肝转移和多发肺转移。进行了B级根治性切除，并实施了由肝动脉注射5-氟尿嘧啶（5-FU）和全身给予伊立替康（CPT-11）组成的交替辅助化疗。发现肺部复发且未观察到化疗的抗肿瘤效果，因此将原本每隔一周给药一次的CPT-11改为每周给药一次，剂量为60mg/体，为原剂量的一半。此外，每天给予5'-脱氧氟尿苷（5'-DFUR），剂量为800mg/天。结果，肺转移瘤明显缩小。恶心、呕吐和脱发等不良事件减轻，未观察到其他毒性反应。因此，该患者能够在门诊极其安全地接受治疗。这被认为是一个有价值的病例，提示了CPT-11与5'-DFUR联合化疗的意义以及CPT-11合理给药的重要性。
