Richenbacher W E, Seemuth S C
The University of Iowa College of Medicine, Iowa City, 52242, USA.
ASAIO J. 2001 Nov-Dec;47(6):590-5. doi: 10.1097/00002480-200111000-00004.
Patients who are supported with an implantable ventricular assist device (VAD) as a bridge to cardiac transplantation are potential candidates for hospital discharge. Hospital discharge rates in reported clinical series vary from 27% to 60%. Many of the patients included in these series, however, were subjects of premarket approval clinical trials and as such, are bound by rigid eligibility criteria for discharge. According to a voluntary registry maintained by Thermo Cardiosystems, Inc., the postmarket discharge rate in patients supported with the HeartMate VE LVAS is approximately 25%, a number that is artificially low due to incomplete reporting. The postmarket discharge rate at the busiest Thermo Cardiosystems HeartMate VE LVAS centers is 53%. Clearly, discharge rates need to increase if the VAD is ever to be considered a viable destination therapy for end-stage heart failure. The discharge program instituted at The University of Iowa incorporates patient and family training as well as community services education. Between January 1999 and April 2001, fourteen patients received VAD support as a bridge to transplantation with the HeartMate VE LVAS. Thirteen patients (93%) were discharged from the hospital. Eight of the 13 patients have been transplanted after having spent 65.8% +/- 31.4% of their period of blood pump support as an outpatient. Eight of 13 patients (62%) required a total of 20 unplanned repeat hospitalizations. A well defined, aggressively implemented discharge program can adequately prepare the VAD patient for the transition from hospital to home.
作为心脏移植桥梁而接受植入式心室辅助装置(VAD)支持的患者是有可能出院的。在已报道的临床系列中,出院率从27%到60%不等。然而,这些系列中纳入的许多患者是上市前批准临床试验的受试者,因此受到严格的出院资格标准限制。根据Thermo Cardiosystems公司维护的一个自愿登记系统,接受HeartMate VE LVAS支持的患者的上市后出院率约为25%,由于报告不完整,这个数字人为地偏低。Thermo Cardiosystems公司HeartMate VE LVAS最繁忙的中心的上市后出院率为53%。显然,如果VAD要被视为终末期心力衰竭的一种可行的目标治疗方法,出院率需要提高。爱荷华大学制定的出院计划包括患者及家属培训以及社区服务教育。在1999年1月至2001年4月期间,14名患者接受了VAD支持作为移植桥梁,使用的是HeartMate VE LVAS。13名患者(93%)出院。13名患者中有8名在作为门诊患者度过了血泵支持期的65.8%±31.4%后接受了移植。13名患者中有8名(62%)总共需要20次计划外的再次住院治疗。一个定义明确、积极实施的出院计划可以让VAD患者充分做好从医院过渡到家庭的准备。