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内源性肝素活性缺乏：动脉粥样硬化形成中的“缺失环节”？

Endogenous heparin activity deficiency: the 'missing link' in atherogenesis?

作者信息

Engelberg H

机构信息

Cedars Sinai Medical Center, Los Angeles, CA 90210, USA.

出版信息

Atherosclerosis. 2001 Dec;159(2):253-60. doi: 10.1016/s0021-9150(01)00650-5.

DOI:10.1016/s0021-9150(01)00650-5
PMID:11730804
Abstract

This paper reviews published studies since 1995 dealing with many atherogenic mechanisms where exogenous heparin was beneficial. In these areas endogenous heparin deficiency is likely to be harmful. Mechanisms included inflammatory factors, lower endogenous plasma heparin levels, lipoprotein lipase, chemokines, APOE e4, lipoprotein(a), among others. Demonstrated reduction of heparan sulfate proteoglycans (HSPG) and of endogenous plasma heparin was reviewed.

摘要

本文回顾了自1995年以来发表的关于多种外源性肝素有益的动脉粥样硬化机制的研究。在这些领域，内源性肝素缺乏可能是有害的。机制包括炎症因子、内源性血浆肝素水平降低、脂蛋白脂肪酶、趋化因子、APOE e4、脂蛋白(a)等。文中还综述了硫酸乙酰肝素蛋白聚糖(HSPG)和内源性血浆肝素的减少情况。

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