Mendes E G
An Acad Bras Cienc. 1976;47:101-4.
This paper reports the results of a pharmacological survey of drug action on muscle preparations of the anthozoan Bunodosoma caissarum. A critical review of previous results of drug action on Coelenterate neuromuscular junction is also given. The preparations responded only to body wall homogenates and acetylcholine. Sympathomimeticamines (adrenaline and nor-adrenaline), indolalkylamines (tryptamine, serotonin) and other drugs (tyramine, histamine, 1-glutamate and GABA) showed no action. The view that the Coelenterates do not employ acetylcholine as a neurotransmitter is discussed.
本文报道了对珊瑚虫Bunodosoma caissarum肌肉制剂进行药物作用药理学调查的结果。同时还对先前关于药物对腔肠动物神经肌肉接头作用的结果进行了批判性综述。这些制剂仅对体壁匀浆和乙酰胆碱有反应。拟交感神经胺(肾上腺素和去甲肾上腺素)、吲哚烷基胺(色胺、5-羟色胺)和其他药物(酪胺、组胺、L-谷氨酸和γ-氨基丁酸)均无作用。文中讨论了腔肠动物不将乙酰胆碱用作神经递质的观点。