库拉索芦荟化学成分的降压作用。
Hypotensive effect of chemical constituents from Aloe barbadensis.
作者信息
Saleem R, Faizi S, Siddiqui B S, Ahmed M, Hussain S A, Qazi A, Dar A, Ahmad S I, Qazi M H, Akhtar S, Hasnain S N
机构信息
Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan.
出版信息
Planta Med. 2001 Nov;67(8):757-60. doi: 10.1055/s-2001-18348.
Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).
已对库拉索芦荟中的芦荟大黄素、芦荟苷A、埃尔戈尼卡二聚体A和双苯并吡喃的降压作用进行了研究。在当前的药理学研究中，芦荟大黄素已成为一种有效的降压剂，在大鼠中，相应剂量为0.5、1和3mg/kg时，平均动脉血压分别下降了26%、52%和79%。该论文还描述了埃尔戈尼卡二聚体A(1)的绝对构型。
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