Tian Bing, Hua Yue-jin, Ma Xiao-qiong, Wang Guan-lin
Department of Applied Bioscience, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, Zhejiang, China.
Zhongguo Zhong Yao Za Zhi. 2003 Nov;28(11):1034-7.
To investigate the relationship between the antibacterial activity of aloe and its contents of anthaquinone compounds, measure and compale antibacterial activities of aloin and aloe-emodin, and analyse the effect of glycoside on the antibacterial activity of aloin.
The antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria were investigated with the method of agar diffusion. The antibacterial effect of aloin on E. coli was further studied with scanning electron microscopy.
The antibacterial activities of aloe showed to be dependent on the dose of anthraquinone, aloin (1 g x L(-1)) exhibited higher antibacterial activity [inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin (inhibition diameter < 5.0 mm), and aloin changed the morphology of E. coli and damaged the outer cell structrue.
Anthraquinone compounds are the active antibacterial components in aloe and aloin is the main active compound. The glycoside makes it easy for aloin to invade cells and enhances its activity.
研究芦荟抗菌活性与其蒽醌类化合物含量之间的关系，测定并比较芦荟苷和芦荟大黄素的抗菌活性，分析糖苷对芦荟苷抗菌活性的影响。
采用琼脂扩散法研究皂质芦荟外叶提取物、芦荟苷和芦荟大黄素对3种革兰氏阴性菌和2种革兰氏阳性菌的抗菌活性。利用扫描电子显微镜进一步研究芦荟苷对大肠杆菌的抗菌作用。
芦荟的抗菌活性显示出依赖于蒽醌剂量，芦荟苷（1 g·L⁻¹）表现出比芦荟大黄素更高的抗菌活性[抑菌直径 > (7.1 ± 0.15) mm]（芦荟大黄素抑菌直径 < 5.0 mm），且芦荟苷改变了大肠杆菌的形态并破坏了其外部细胞结构。
蒽醌类化合物是芦荟中的活性抗菌成分，芦荟苷是主要的活性化合物。糖苷使芦荟苷易于侵入细胞并增强其活性。
