Domzał-Stryga A, Bojakowski J
Katedra i Klinika Neurologii AM w Warszawie.
Neurol Neurochir Pol. 2001;35(1 Suppl):71-80.
Results obtained during transcranial magnetic stimulation (TMS) in 79 patients with ALS were compared to those obtained in 10 healthy volunteers. M and F responses evoked by peripheral stimulation of the ulnar and peroneal nerves and then motor evoked potentials (MEP) induced by TMS were recorded in the abductor digiti quinti (AV) and tibial anterior (TA) muscles bilaterally. Central motor conduction time (CMCT) was calculated using MEP and F response latencies. The MEP/M x 100% amplitude ratios were calculated. Mean CMCT was significantly (p < 0.0001) prolonged in patients with ALS (9.6 +/- 4.1 ms for AV and 20.4 +/- 9.6 ms for TA) and MEP/M x 100% amplitude ratios were higher (45 +/- 75% for AV-p < 0.001 and 27 +/- 32.7% for TA p = 0.2). In a sub-group of patients with predominant upper motor neuron (UMN) involvement, the CMCT was significantly prolonged (14.2 +/- 5.8 ms for AV and 28.5 +/- 9.1 ms for TA), but MEP/M x 100% amplitude ratio was 24.1 +/- 37.6% for AV and 11.4 +/- 12.9% TA. These results confirm usefulness of combined analysis of CMCT and MEP/M x 100% amplitude ratio as the method of assessment of pyramidal tract function in ALS.
对79例肌萎缩侧索硬化症（ALS）患者经颅磁刺激（TMS）的结果与10名健康志愿者的结果进行了比较。双侧记录尺神经和腓神经外周刺激诱发的M波和F波反应，以及TMS诱发的运动诱发电位（MEP），记录部位为小指展肌（AV）和胫骨前肌（TA）。使用MEP和F波反应潜伏期计算中枢运动传导时间（CMCT）。计算MEP/M×100%振幅比。ALS患者的平均CMCT显著延长（AV为9.6±4.1毫秒，TA为20.4±9.6毫秒，p<0.0001），MEP/M×100%振幅比更高（AV为45±75%，p<0.001；TA为27±32.7%，p = 0.2）。在以主要累及上运动神经元（UMN）的患者亚组中，CMCT显著延长（AV为14.2±5.8毫秒，TA为28.5±9.1毫秒），但AV的MEP/M×100%振幅比为24.1±37.6%，TA为11.4±12.9%。这些结果证实了联合分析CMCT和MEP/M×100%振幅比作为评估ALS锥体束功能方法的有效性。
