Anthony F, Acar J, Franklin A, Gupta R, Nicholls T, Tamura Y, Thompson S, Threlfall E J, Vose D, van Vuuren M, White D G
Université Pierre et Marie Curie, Service de Microbiologie Médicale, Fondation Hôpital Saint-Joseph, 185 rue Raymond Losserand, 75674 Paris, France.
Rev Sci Tech. 2001 Dec;20(3):829-39. doi: 10.20506/rst.20.3.1318.
A guideline on the responsible and prudent use of antimicrobials in animal husbandry has been developed by the Ad hoc Group of experts on antimicrobial resistance, created by the Office International des Epizooties. The objectives of responsible use are to maintain antibiotic efficacy, to avoid the dissemination of resistant bacteria or resistance determinants and to avoid the exposure of humans to resistance through food. The guideline attributes a central role to the competent authorities responsible for granting marketing authorizations for antimicrobial substances. Requirements before and after granting of marketing authorizations are defined. Important aspects include the control of the pharmaceutical product quality and the therapeutic efficacy, the assessment of the selection pressure, the protection of the environment, specific and non-specific antimicrobial resistance surveillance. The guideline is also addressed to the veterinary pharmaceutical industry, veterinary practitioners, dispensing pharmacists and farmers. The respective roles and responsibilities of these groups are defined.
国际兽疫局设立的抗菌药物耐药性特设专家组制定了一份关于在畜牧业中合理谨慎使用抗菌药物的指南。合理使用的目标是维持抗生素疗效，避免耐药菌或耐药决定因子的传播，并避免人类通过食物接触耐药性。该指南赋予负责授予抗菌物质上市许可的主管当局核心作用。定义了授予上市许可之前和之后的要求。重要方面包括药品质量和治疗效果的控制、选择压力的评估、环境保护、特异性和非特异性抗菌药物耐药性监测。该指南也面向兽药行业、兽医从业者、配药药剂师和养殖者。明确了这些群体各自的角色和责任。
